nano emulsions

  

NanoGenizer High Pressure Homogenizer:

NanoGenizer is a laboratory high pressure processing device. It is an electrically-driven and bench-top, high pressure homogenizer requiring no compressed air or hydraulic oil to achieve maximum 3,062 bar (45,000 psi) operating pressure. NanoGenizer high pressure homogenizer is composed of a feed reservoir, high pressure pump, transducer, PLC control panel and microfluidics diamond interaction chamber. The sanitary pump system of the NanoGenizer high pressure homogenizer is able to supply the desired pressure to the product stream and push it through the micron chamber (microreactor) to create high shear rates and strong impact within the stream. This process results in uniform particle distribution and smaller particle sizes.

Application of NanoGenizer High Pressure Homogenizer:

Cell disruption and particle size reduction Nano emulsions  Nano dispersions Liposomes Deagglomeration Vaccine production

Performance of NanoGenizer High Pressure Homogenizer:

Energy efficient, 1/2 energy loss of the most homogenizers Small (integrated design delivers the light weight and small dimensions) Smart (programming control systems confer diligent functions: controlled inlet volume ± 0.1mL; auto stop with time/volume) Silent (noiseless performance) Strong (more than 150 mL/min at 30,000 psi) CE compliant and RoHs compliant

Troubleshooting:

Our design has minimized the occurrence of air-blocking, chamber-blocking and overload.

However, the improper operation of the homogenizer can still induce errors and cause damage to the homogenizer.

Air Blocking

Symptom: there is no pressure and no sucking from inlet

Prevention: do not run with empty inlet

Reason: there is air inside the pump

Solutions:

1) In the customer setup, push the button called Degas

2) Running 50mL water with 50% speed

3) Push the ball into the inlet valve with a pin

Chamber Blocking

Symptom: overload of the pressure

Prevention: pre-treat the sample carefully; reduce the speed

Reason: there are aggregates or particles in the sample; too high a speed

Solutions:

1) Reverse flow the outlet valve with 100mL water with low speed

2) Reverse flow the chamber with water from low to high speed

Overload

Solutions:

1) Reduce the speed and close the power, wait 30 sec and restart

2) Wash with water or solvent

3) Run with clean and homo-disperse sample

Air blocking rarely causes damage to the NanoGenizer; however, the chamber blocking is harmful to the pump because of overloaded pressure in an instant.

1) Pretreat the sample carefully, and always use a clean and homo-disperse sample

2) Adjust the pressure from low to high

3) For safety, do not point the inlet or outlet of high pressure devices and equipment supplied by Genizer, including high pressure homogenizer, extruder, interaction chamber and valve, to any personnel or object that may affect safety or induce property loss.

Tips:

For facilitating the user applications, the two ports in the high pressure cylinder of the NanoGenizer are exchangeable for inlet and outlet.

https://www.genizer.com/nanogenizer_p0039.html